2009-2010 Undergraduate Catalog

Chemistry

Students may complete a major or minor in Chemistry. Within the major, students may complete a minor in computational methods or education. Concentrations in biological chemistry, environmental studies or geochemistry may be completed within the major. Students may complete an M.A. in the combined A.B./M.A. program.

Faculty

Alyssa Anne Bohen, Instructor
Sharon J. Nieter Burgmayer, Professor (on leave semester I)
Michelle Miller Francl-Donnay, Professor
Jonas I. Goldsmith, Assistant Professor
Stephanie Lim, Bucher-Jackson Postdoctoral Fellow
Krynn DeArman Lukacs, Senior Lecturer
William P. Malachowski, Associate Professor (on leave semester II)
Frank B. Mallory, Professor (on leave semesters I and II)
Maryellen Nerz-Stormes, Senior Lecturer
Silvia L. Porello, Lecturer
Susan A. White, Professor and Chair

The undergraduate course program in Chemistry is designed to give students a sound background in both theoretical and practical aspects of four main fields: organic chemistry, physical chemistry, inorganic chemistry and biological chemistry. Furthermore, students may design courses of study that emphasize chemistry’s connections to biology, earth sciences and computer science. Laboratory work is emphasized to provide students with modern training in experimental skills and analytical techniques. The core program, consisting of courses at the 100 level and 200 level, covers fundamental principles of chemistry. This core program provides the basis for advanced work at the 300 level and 400 level, in which students encounter contemporary problems in chemistry and interdisciplinary fields and the progress that is being made toward solving them.

The Department of Chemistry offers several elective courses and half courses at the introductory level for a general audience on such topics as drugs, scientific writing, and art. Students intending to take chemistry courses must take a chemistry placement test. Extraordinarily well-prepared students may start with CHEM 211 or CHEM 104; most students will start with CHEM 103 and some will be placed into CHEM 101.

Major Requirements

The requirements for a standard Chemistry major include the following 11 courses (or their equivalents): CHEM 103, 104, 211, 212, 221, 222, 231, 242, 251 and 252, and any two chemistry courses at the 300 or 500 level. Other required courses are MATH 101, 102 and 201 and PHYS 121/122 or 101/102 (or their equivalents). PHYS 121/122 is the recommended sequence. Students who have completed 101/102, as well as any students planning graduate work in chemistry, should consider taking PHYS 201. All A.B. recipients who complete this program with two semesters of CHEM 403 are certified by the American Chemical Society as having met that society’s high standards for an undergraduate degree in chemistry. This is the program recommended for students intending to pursue graduate studies in chemistry.

Majors are encouraged to take additional chemistry courses at the 300 (or 500) level and at the 400 (research) level beyond the requirements of the standard program. Additional courses in mathematics and other natural sciences can contribute breadth to the chemistry major. Students with a strong interest in an allied field, such as biochemistry, geochemistry, environmental chemistry, computational chemistry or education may elect a minor or concentration in the appropriate field. Upon consultation with major advisers in both fields students may select three of the four core courses, 221, 222, 231 and 242, and appropriate 300-level electives.

A typical schedule for the standard chemistry major involves taking CHEM 103 and 104 and MATH 101/102 in the first year; CHEM 211 and 212, MATH 201, and PHYS 121/122 or 101/102 in the sophomore year; CHEM 221, 222, 231, 242, 251 and 252 in the junior year; and appropriate advanced courses in the senior year. Note that MATH 201 (a fall course) or its equivalent should be completed by the end of the sophomore year. Students contemplating a chemistry major are urged to consult with the major adviser as early as possible. Those planning an interdisciplinary chemistry major should consult advisers in both departments as soon as possible.

Honors

The A.B. degree with honors in chemistry will be awarded to students who complete the major in chemistry and also meet the following further requirements: two semesters of supervised research in chemistry (CHEM 403) with a grade of at least 3.3 in each semester; the submission of an acceptable paper describing the results of that research; an additional semester of work at the 300 level (or 500 level) in chemistry beyond the two advanced courses required for the standard chemistry major; and a grade point average, calculated at the end of the senior year, of at least 3.7 in all chemistry courses taken.

Minor Requirements

A student may qualify for a minor in chemistry by completing a total of 6.5 courses in chemistry, one of which must be either CHEM 221 or 222 with either CHEM 251 or 252. BIOL 375 and 376 may be counted as one of the required six courses. At least two of the six courses must be taken at Bryn Mawr.

Minor in Computational Methods

Students may receive an A.B. degree in chemistry with a computational minor by fulfilling the core requirements in chemistry (CHEM 103, 104, 211, 212, 251 and 252) and three courses selected from 221, 222, 231 and 242, two advanced courses including CHEM 322 and CMSC 376, and by completing CMSC 110 or 205, 206, 231 and one of the following: 212, 225, 245, 246, 330, or 340. The courses selected to fulfill this minor must be approved by the major advisers in Chemistry and Computer Science.

Minor in Education

Students may receive an A.B. degree in chemistry with an education minor by fulfilling the core requirements in chemistry (CHEM 103, 104, 211, 212, 251 and 252) and three courses selected from 221, 222, 231 and 242, three advanced courses selected from CHEM 403 or electives in chemistry or education, and by completing EDUC 200, 310, 311 and 240 or 250. The courses selected to fulfill this minor must be approved by the major advisers in Chemistry and Education. Of the three advanced courses, at least one must be a chemistry course at or above the 300 level. Interested students are encouraged to investigate the 5th-year certification option offered through the Education Program.

Concentration in Biological Chemistry

Students may receive an A.B. degree in chemistry with a concentration in biological chemistry by fulfilling the core requirements in chemistry (CHEM 103, 104, 211, 212, 251 and 252) and three courses selected from 221, 222, 231 and 242, and any two chemistry courses at the 300 or 500 level, including CHEM 345 as one of the two required advanced courses. Students must also complete two semesters of work in biology selected from BIOL 201, 255, or 340, and BIOL 376 or their Haverford equivalents. The two biology courses chosen to fulfill this requirement must be approved by the major adviser.

Concentration in Environmental Studies

Students may receive an A.B. degree in chemistry with a concentration in environmental studies by fulfilling the core requirements in chemistry (CHEM 103, 104, 211, 212, 251, 252) and three courses selected from 221, 222, 231 and 242, two advanced courses including a chemistry elective and GEOL 302 or 397, and by completing BIOL 220 and GEOL 103 and one course listed under “Humans in the Environment” and two courses listed under “Planning and Policy”. The courses selected to fulfill this concentration must be approved by the major advisers in Chemistry and Environmental Studies.

Concentration in Geochemistry

Students may receive an A.B. degree in chemistry with a concentration in geochemistry by fulfilling the core requirements in chemistry (CHEM 103, 104, 211, 212, 251, 252) and three courses selected from 221, 222, 231 and 242, one advanced course selected from CHEM 322 or 332, and by completing three geology courses selected from GEOL 201, 202, 301 or 302. The courses selected to fulfill this concentration must be approved by the major advisers in Chemistry and Geology.


A.B./M.A. Program

To earn an M.A. degree in chemistry in the College’s A.B./M.A. program, a student must complete the requirements for an undergraduate chemistry major and also must complete six units of graduate level work in chemistry. Of these six units, as many as two units may be undergraduate courses at the 300 level taken for graduate credit (these same two courses may be used to fulfill the major requirements for the A.B. degree), at least two units must be graduate seminars at the 500 level, and two units must be graduate research at the 700 level leading to the submission of an acceptable M.A. thesis. Other requirements are a written final examination covering material in the candidate’s special field and an oral examination.

CHEM B100 The Stuff of Art
An introduction to chemistry through fine arts, this course emphasizes the close relationship of the fine arts, especially painting, to the development of chemistry and its practice. The historical role of the material in the arts, in alchemy and in the developing science of chemistry, will be discussed, as well as the synergy between these areas. Relevant principles of chemistry will be illustrated through the handling, synthesis and/or transformations of the material. This course does not count towards chemistry major requirements, and is not suitable for premedical programs. Lecture 90 minutes, laboratory three hours a week. Enrollment limited to 20.
(Burgmayer, Division II with Lab)
Cross-listed as HART B100
Not offered in 2010-11.

CHEM B101 Chemistry Fundamentals
For students with little background in chemistry. Prepares students for CHEM 103 by covering problem-solving techniques, mathematics needed for chemistry, atoms, molecules, chemical structures, chemical reactions and solutions. Depending on interest, there may be a topical focus such as drugs and doses, food and energy, or the environment. The course may include Individual student conferences and electronic resources. Offered in the second half of the Fall and Spring semesters. Enrollment is based on performance on a placement test or permission of the instructor.
(Francl, Porello, Division II: Natural Science)
This is a half-semester, half-credit course.

CHEM B103 General Chemistry I
For students with some background in chemistry. Sections usually have a maximum of 50 students. Topics include aqueous solutions and solubility; the electronic structure of atoms and molecules; radiochemistry. Examples in lecture and laboratory include environmental sciences, material sciences and biological chemistry. Lecture three hours, recitation one hour and laboratory three hours a week. May include individual conferences, evening problem or peer-led instruction sessions. Laboratory is offered Monday, Tuesday, or Wednesday in the Fall, and on Thursday in the Spring.
(Francl, Lukacs, Porello, White, Division II with Lab and Quantitative Skills)

CHEM B104 General Chemistry II
A continuation of CHEM 103 . Topics include chemical reactions; introduction to thermodynamics and chemical equiibria; acid-base chemistry; electrochemistry; chemical kinetics. Lecture three hours, recitation one hour and laboratory three hours a week. May include individual conferences, evening problem or peer-led instruction sessions. Prerequisite: CHEM 103 with a grade of at least 2.0, strong performance on the chemistry placement test. Laboratory is offered on Monday, Tuesday, or Wednesday in the Spring or on Thursday in the Fall.
(Goldsmith, Interim, Lukacs, Porello, Division II with Lab and Quantitative Skills)

CHEM B105 Intimate Interactions Chemical Bonding
This half-semester course will focus on chemical bonding, starting with the simplest bonding models and describing how these develop into more complex bonding models. The aim is to integrate bonding concepts that are currently taught in separate courses to present a unified evolution of bonding theories. Prerequisite: CHEM B104 or equivalent.
(Burgmayer, Division II: Natural Science)

CHEM B116 Drugs and How They Work
An introductory half course exploring fundamental structure-related principles in chemistry through a study of drug action. Prerequisite: CHEM B103 or equivalent or permission of the instructor.
(Malachowski, Division II: Natural Science)
This is a half-semester, half-credit course.

CHEM B125 Writing Science
How does scientific research make its way out of the lab? Science translates from research experience to journals written for the expert and is often translated again for more general audiences—appearing in venues such as newspapers, essays and memoirs. What is gained and what is lost when science is translated?
(Francl-Donnay)
Cross-listed as ARTW B125
This is a half-semester, half-credit course.

CHEM B211 Organic Chemistry I
An introduction to the principles of organic chemistry, including synthetic and spectroscopic techniques. Lecture three hours, recitation one hour and laboratory five hours a week. Prerequisite: CHEM 104 with a grade of at least 2.0.
(Bohen, Nerz-Stormes, Division II with Lab)

CHEM B212 Organic Chemistry II
A continuation of CHEM 211 with an exploration of complex chemical reactions and syntheses utilizing structure-reactivity principles. Lecture three hours, recitation one hour and laboratory five hours a week. Prerequisite: CHEM 211 with a grade of at least 2.0.
(Bohen, Nerz-Stormes, Division II with Lab)

CHEM B221 Physical Chemistry I
Introduction to quantum theory and spectroscopy. Atomic and molecular structure; molecular modeling; rotational, vibrational, electronic and magnetic resonance spectroscopy. Lecture three hours. Prerequisites: CHEM 104, PHYS 121 or 103 and MATH 201. May be taken concurrently with CHEM 211 and PHYS 121 or 103.
(Francl-Donnay, Division II: Natural Science)

CHEM B222 Physical Chemistry II
Modern thermodynamics, with application to phase equilibria, interfacial phenomena and chemical equilibria; statistical mechanics; chemical dynamics. Kinetic theory of gases; chemical kinetics. Lecture three hours. Prerequisites: CHEM 104, PHYS 122 or 102 and MATH 201. May be taken concurrently with CHEM 212 and PHYS 122 or 102.
(Goldsmith, Division II: Natural Science)

CHEM B231 Inorganic Chemistry
Bonding theory; structures and properties of ionic solids; symmetry; crystal field theory; structures, spectroscopy, stereochemistry, reactions and reaction mechanisms of coordination compounds; acid-base concepts; descriptive chemistry of main group elements. Lecture three hours a week. Prerequisite: CHEM 212.
(Burgmayer, Division II: Natural Science)

CHEM B242 Biological Chemistry
The structure, chemistry and function of amino acids, proteins, lipids, polysaccharides and nucleic acids; enzyme kinetics; metabolic relationships of carbohydrates, lipids and amino acids, and the control of various pathways; protein synthesis. Lecture three hours a week. Prerequisite: CHEM 212.
(White, Division II: Natural Science)

CHEM B251 Research Methodology in Chemistry I
This laboratory course integrates advanced concepts in chemistry from biological, inorganic, organic and physical chemistry. Students will gain experience in the use of departmental research instruments and in scientific literature searches, quantitative data analysis, record-keeping and writing. One hour of lecture and five hours of laboratory per week. Prerequisite: CHEM 212. Corequisite: CHEM 221 or 242. 0.5 credit/semester.
(Francl-Donnay, Malachowski)

CHEM B252 Research Methodology in Chemistry II
This laboratory course integrates advanced concepts in chemistry from biological, inorganic, organic and physical chemistry. Students will gain experience in the use of departmental research instruments and in scientific literature searches, quantitative data analysis, record-keeping and writing. One hour of lecture and five hours of laboratory per week. Prerequisite: CHEM 212. Corequisite: CHEM 222 or 231.
(Porello, White)

CHEM B311 Advanced Organic Chemistry
A survey of the methods and concepts used in the synthesis of complex organic molecules. Lecture three hours a week. Prerequisites: CHEM 212 and 222.
(Malachowski, Division II: Natural Science)
Not offered in 2010-11.

CHEM B312 Advanced Organic Chemistry
Principles of physical organic chemistry with emphasis on reaction mechanisms, reactive intermediates and stereochemistry. Lecture three hours a week. Prerequisites: CHEM 212 and 222.
(Mallory, Division II: Natural Science)
Not offered in 2010-11.

CHEM B315 Medicinal Chemistry
A survey of topics related to drug discovery including lead discovery, target interactions, structural optimization, drug metabolism, and drug synthesis. The course will engage in an advanced treatment of these topics with particular attention to an understanding of drug design and development on the molecular level. Case studies will be used to illustrate the application of these principles. Discussions may include OxyContin and related opiate analgesics; aspirin and related NSAIDs; penicillin and other antibacterial agents; Tamiflu and related anti-virals; Alzheimer’s disease drugs; and anti-depressants. Prerequisites: CHE 212 or the equivalent.
(Malachowski)

CHEM B321 Advanced Physical Chemistry
Topics vary. Prerequisites: CHEM 221 and 222 or permission of the instructor. Lecture/seminar three hours per week.
(Francl-Donnay, Goldsmith, Division II: Natural Science)
Not offered in 2010-11.

CHEM B322 Advanced Physical Chemistry
Topics vary. Prerequisites: MATH 201 and at least junior-level standing in a science major or permission of the instructor.
(Francl-Donnay, Division II: Natural Science)
Not offered in 2010-11.

CHEM B332 Advanced Inorganic Chemistry
A survey of metals in biology illustrating structural, enzymatic and pharmaceutical applications of transition metals in biological chemistry and including discussion of structural themes and bonding, reaction types, and catalysis. Lecture three hours per week. Prerequisites: CHEM 231 and 242 or permission of the instructor.
(Burgmayer, Division II: Natural Science)

CHEM B345 Advanced Topics in Biological Chemistry (Fall 2010): Nucleic Acids Biochemistry and Applications in Biology
The course introduces students to the biochemistry of DNA and RNA and related cellular metabolism. It also explores novel biotechnological applications in several areas including medical diagnosis and treatment, genetically modified crops, forensics, bioinformatics, and genome sequencing, among others. The course includes oral presentations as well as written assignments.
(Porello, Division II: Natural Science)

CHEM B345 Advanced Topics in Biological Chemistry (Spring 2011): Current Topics in Metabolism
During the first part of the semester, metabolic pathways not covered in CHEM 242 will be covered. Biosynthesis and breakdown of carbohydrates, fats, amino acids, and other molecules will be discussed. Current literature about obesity, diabetes, and other metabolic diseases will be discussed in a seminar format. Students will have problem sets as well as written and oral presentations. Prerequisite: any course in biochemistry.
(White, Division II: Natural Science)

CHEM B350 Selected Topics in Current Chemical Research
A combination lecture/seminar course on the physical, structural, chemical, photochemical, mechanistic and spectroscopic properties of novel organic compounds, including oral presentations by students on very recently published research articles. Lecture three hours a week. Prerequisites: CHEM 211-212, CHEM 221-222, and any 300/500 level course in organic, physical, inorganic or biological chemistry.
(Guron, Division II: Natural Science)
Not offered in 2010-11.

CHEM B403 Supervised Research
Many individual research projects are available, each under the supervision of a member of the faculty. Laboratory at least 10 hours a week. Oral or written presentations are required at the end of each semester. Prerequisite: permission of faculty supervisor.
(Burgmayer, Francl-Donnay, Goldsmith, Malachowski, Mallory, White)