Timetable for Chemistry 345/545

Week of	Topic	Reading
September 2	DNA Metabolism and Techniques	Stryer Chap. 27 Sheehan 5.4, 5.8, 5.11
September 9	RNA and Protein Biosynthesis	Stryer 28, 29
September 16	Viral lifestyles	Microbe Hunter--Anthrax
September 23	Malaria and Drug Design Strategies	Microbe Hunter—Malaria Ridley—Malaria Drugs
September 30	Producing Protein Targets	Sheehan—Ch. 2.4
October 7	Protein Analysis Measuring MW and activities	Sheehan—Ch. 4 and Ch. 7
Fall Break		Fall Break
October 21	Seeing Proteins	Sheehan—Ch 3.7 and Ch. 6
October 28	NMR	Staple and Butcher—“Solution structure of the HIV-1 frameshift inducing stem-loop RNA”
November 4		Visit to Glaxo-Smith-Kline- (date TBA)
November 11	Crystallography	Bernstein et al. “Structural Insights into the Activation of P. vivax Plasmepsin”
November 18	UV/Vis and Fluorescence	Sheehan—Ch. 3.3 and 3.4 Flotow et al. “Development of a Plasmepsin II Fluorescence Polarization Assay Suitable for High Throughput Antimalarial Drug Discovery”
November 25	Circular Dichroism	Sheehan 3.5 Dwyer et al. “The Hydrophobic pocket contributes to the structural stability of the N-terminal coiled coil of HIV gp41”
Thanksgiving
December 2	Genomics	Le Roch et al.--"Discovery of Gene Function by Profiling of the Malaria Parasite Life Cycle"
December 9	Proteomics	Lasonder et al. "Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry"
Final Exam