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Publications
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17. “Enantioselective synthesis of bicarbocyclic structures with an all-carbon
quaternary stereocenter through sequential cross metathesis and
intramolecular Rauhut–Currier reaction” Yuan Qiao,* Sanjeev Kumar,*** and William P. Malachowski. Tetrahedron Lett.
2010, 51(19), 2636-2638.
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16. “Structure Based Development
of Phenyl-imidazole-derived Inhibitors of Indoleamine 2,3-Dioxygenase” Sanjeev Kumar,*** Daniel Jaller, Bhumika Patel,* Judith M. LaLonde, James B. DuHadaway, William P. Malachowski, George C. Prendergast
and Alexander J. Muller. J. Med.
Chem. 2008 51(16), 4968-4977.
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15. “Indoleamine
2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent
Naphthoquinone-Based Inhibitors” Sanjeev Kumar,***
William P. Malachowski, James B. DuHadaway, Judith
M. LaLonde, Patrick J. Carroll, Daniel Jaller, Richard Metz, George C. Prendergast, and
Alexander J. Muller J. Med. Chem. 2008, 51(6), 1706-1718.
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14. “A key in
vivo antitumor mechanism of action of natural product-based brassinins is
inhibition of indoleamine 2,3-dioxygenase” T. Banerjee,
J.B. DuHadaway, P. Gaspari,**
E. Sutanto-Ward, D.H. Munn, A.L. Mellor, W.P.
Malachowski, G.C. Prendergast and A.J. Muller. Oncogene
2008, 27(20), 2851-2857 .
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13. "The Enantioselective Synthesis of (-)-Lycoramine with the Birch-Cope Sequence" William P. Malachowski, Tapas Paul***, and Sophia Phounsavath*. J. Org. Chem. 2007, 72(18), 6792-6796.
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12. "Exploration of the
Enantioselective Birch-Cope Sequence for the Synthesis of Carbocyclic
Quaternary Stereocenters" Tapas Paul***, William P. Malachowski,
and Jisun Lee*. J. Org. Chem. 2007,
72(3), 930-937.
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11. "The Enantioselective
Birch-Cope Sequence for the Synthesis of Carbocyclic Quaternary
Stereocenters. Application to the Synthesis of (+)-Mesembrine"
Tapas Paul***, William P. Malachowski, and Jisun Lee*. Org. Lett. 2006
8(18), 4007-4010.
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10. "Structure-Activity Study of Brassinin Derivatives as Indoleamine
2,3-Dioxygenase Inhibitors" Paul Gaspari**, Tinku Banerjee, William P.
Malachowski, Alexander J. Muller, George C. Prendergast, James DuHadaway, Shauna Bennett* and Ashley Donovan*. J.
Med. Chem. 2006, 49(2), 684-692.
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9.
"A New Cancer Immunosuppression Target: Indoleamine 2,3-Dioxygenase
(IDO). A Review of the IDO Mechanism, Inhibition and Therapeutic
Applications" William P.
Malachowski, Richard Metz, George Prendergast and Alexander J. Muller. Drugs
of the Future 2005, 30(9), 897-909.
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8. "A general
strategy for the synthesis of azapeptidomimetic lactams" Robert L. Broadrup**,
Bei Wang** and William P. Malachowski. Tetrahedron
2005, 61(43), 10277-10284.
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7. "Indoleamine 2,3-dioxygenase in cancer:
targeting pathological immune tolerance with small-molecule inhibitors"
Alexander J. Muller, William P. Malachowski, and George C. Prendergast. Expert
Opin. Ther. Targets 2005,
9, 831-849.
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6. "Sequential
Birch reduction-allylation and Cope Rearrangement
of o-anisic acid derivatives" William P. Malachowski and Marisha Banerji*. Tetrahedron Lett.
2004, 45(44), 8183-8185.
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5. "The Synthesis
of Azapeptidomimetic beta-Lactam
Molecules as Potential Protease Inhibitors" William P. Malachowski, Chenyang Tie**,
Katherine Wang*, and Robert L. Broadrup**. J.
Org. Chem. 2002, 67(25), 8962-8969.
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4. "Asymmetric
Total Synthesis of (+)-Apovincamine and a Formal
Synthesis of (+)-Vincamine. Demonstration of
a Practical 'Asymmetric Linkage' between Aromatic Carboxylic Acids and
Acyclic Substrates" Arthur G. Schultz, William P. Malachowski, and You
Pan. J. Org. Chem.1997, 62(5), 1223-1229.
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3. "The Chemistry
of Phosphapeptides: Formation of
Functionalized Phosphonochloridates Under
Mild Conditions and Their Reaction with Alcohols and Amines" William P.Malachowski and James K. Coward J.Org.Chem. 1994, 59(25),
7616-7624.
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2. "The Chemistry
of Phosphapeptides: Investigations on the Synthesis
of Phosphonamidate, Phosphonate,
and Phosphinate Analogues
of Glutamyl-gamma-Glutamate" William P.
Malachowski and James K. Coward J.Org.Chem.
1994, 59(25), 7625-7634.
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1. "Nature of
the Rate-determining Steps of the Reaction Catalyzed by the Yersinia Protein-tyrosine Phosphatase"
Zhong-Yin Zhang, William P. Malachowski, Robert L.
Van Etten, and Jack E. Dixon J. Biol.
Chem. 1994, 269(11), 8140-8145.
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Patents
| 5. “Imidazole derivatives as IDO inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases” Mario R. Mautino, Sanjeev Kumar, Firoz Jaipuri, Jesse Waldo, Tanay Kesharwani, Nicholas N Vahanian, Charles J. Link, Judith Lalonde, George Prendergast, Alexander Muller, William Malachowski. PCT Int. Appl., WO 2009132238 2009. |
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4. “Preparation of benzochromenedione derivatives for
use as IDO inhibitors” George C. Prendergast, William P. Malachowski, , Alexander J. Muller. PCT Int. Appl. WO 2008115804 2008.
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3.
“Dithiocarbamates as IDO inhibitors and their
preparation, pharmaceutical compositions and their use in the treatment of
diseases” James B. Duhadaway, George C.
Prendergast, William P. Malachowski, Alexander J. Muller. WO 2007050963 2007. |
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2. "Novel IDO (indoleamine 2,3-dioxygenase)
inhibitors and methods of use" George C. Prendergast, Alexander J.
Muller, James B. Duhadaway, and William P.
Malachowski. WO 2004094409 2004. |
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1. "Novel methods for the treatment of cancer and viral infections"
George C. Prendergast, Alexander J. Muller, James B. Duhadaway,
and William P. Malachowski. WO 2004093871 2004. |