Publications
*=undergraduate student
**=graduate student
***=post-doctoral associate

17. “Enantioselective synthesis of bicarbocyclic structures with an all-carbon quaternary stereocenter through sequential cross metathesis and intramolecular Rauhut–Currier reaction” Yuan Qiao,* Sanjeev Kumar,*** and William P. Malachowski. Tetrahedron Lett. 2010, 51(19), 2636-2638.

16. “Structure Based Development of Phenyl-imidazole-derived Inhibitors of Indoleamine 2,3-Dioxygenase” Sanjeev Kumar,*** Daniel Jaller, Bhumika Patel,* Judith M. LaLonde, James B. DuHadaway, William P. Malachowski, George C. Prendergast and Alexander J. Muller. J. Med. Chem. 2008  51(16),  4968-4977.

15. “Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors” Sanjeev Kumar,*** William P. Malachowski, James B. DuHadaway, Judith M. LaLonde, Patrick J. Carroll, Daniel Jaller, Richard Metz, George C. Prendergast, and Alexander J. Muller J. Med. Chem. 2008, 51(6), 1706-1718.

14. “A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase” T. Banerjee, J.B. DuHadaway, P. Gaspari,** E. Sutanto-Ward, D.H. Munn, A.L. Mellor, W.P. Malachowski, G.C. Prendergast and A.J. Muller. Oncogene 2008, 27(20), 2851-2857 .

13. "The Enantioselective Synthesis of (-)-Lycoramine with the Birch-Cope Sequence" William P. Malachowski, Tapas Paul***, and Sophia Phounsavath*. J. Org. Chem. 2007, 72(18), 6792-6796.
     *This article was one of the top twenty accessed articles in the Journal of Organic Chemistry during July-Sept. 2007.

12. "Exploration of the Enantioselective Birch-Cope Sequence for the Synthesis of Carbocyclic Quaternary Stereocenters" Tapas Paul***, William P. Malachowski, and Jisun Lee*. J. Org. Chem. 2007, 72(3), 930-937.

11. "The Enantioselective Birch-Cope Sequence for the Synthesis of Carbocyclic Quaternary Stereocenters. Application to the Synthesis of (+)-Mesembrine" Tapas Paul***, William P. Malachowski, and Jisun Lee*. Org. Lett. 2006 8(18), 4007-4010.

10. "Structure-Activity Study of Brassinin Derivatives as Indoleamine 2,3-Dioxygenase Inhibitors" Paul Gaspari**, Tinku Banerjee, William P. Malachowski, Alexander J. Muller, George C. Prendergast, James DuHadaway, Shauna Bennett* and Ashley Donovan*. J. Med. Chem. 2006, 49(2), 684-692.

9. "A New Cancer Immunosuppression Target: Indoleamine 2,3-Dioxygenase (IDO). A Review of the IDO Mechanism, Inhibition and Therapeutic Applications" William P. Malachowski, Richard Metz, George Prendergast and Alexander J. Muller. Drugs of the Future 2005, 30(9), 897-909.

8. "A general strategy for the synthesis of azapeptidomimetic lactams" Robert L. Broadrup**, Bei Wang** and William P. Malachowski. Tetrahedron 2005, 61(43), 10277-10284.

7. "Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors" Alexander J. Muller, William P. Malachowski, and George C. Prendergast. Expert Opin. Ther. Targets 2005, 9, 831-849.

6. "Sequential Birch reduction-allylation and Cope Rearrangement of o-anisic acid derivatives" William P. Malachowski and Marisha Banerji*. Tetrahedron Lett. 2004, 45(44), 8183-8185.

5. "The Synthesis of Azapeptidomimetic beta-Lactam Molecules as Potential Protease Inhibitors" William P. Malachowski, Chenyang Tie**, Katherine Wang*, and Robert L. Broadrup**. J. Org. Chem. 2002, 67(25), 8962-8969.

4. "Asymmetric Total Synthesis of (+)-Apovincamine and a Formal Synthesis of (+)-Vincamine.  Demonstration of a Practical 'Asymmetric Linkage' between Aromatic Carboxylic Acids and Acyclic Substrates" Arthur G. Schultz, William P. Malachowski, and You Pan.  J. Org. Chem.1997, 62(5), 1223-1229.

3. "The Chemistry of Phosphapeptides: Formation of  Functionalized Phosphonochloridates Under Mild Conditions and Their Reaction with Alcohols and Amines" William P.Malachowski and James K. Coward  J.Org.Chem. 1994, 59(25), 7616-7624.

2. "The Chemistry of Phosphapeptides: Investigations on the Synthesis of Phosphonamidate, Phosphonate, and Phosphinate  Analogues of Glutamyl-gamma-Glutamate" William P. Malachowski and James K. Coward  J.Org.Chem. 1994, 59(25), 7625-7634.

1. "Nature of the Rate-determining Steps of the Reaction Catalyzed by the Yersinia Protein-tyrosine Phosphatase" Zhong-Yin Zhang, William P. Malachowski, Robert L. Van Etten, and Jack E. Dixon  J. Biol. Chem. 1994, 269(11), 8140-8145.

Patents

5. “Imidazole derivatives as IDO inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases” Mario R. Mautino, Sanjeev Kumar, Firoz Jaipuri, Jesse Waldo, Tanay Kesharwani, Nicholas N Vahanian, Charles J. Link, Judith Lalonde, George Prendergast, Alexander Muller, William Malachowski. PCT Int. Appl., WO 2009132238 2009.

4. “Preparation of benzochromenedione derivatives for use as IDO inhibitors” George C. Prendergast, William P. Malachowski, , Alexander J. Muller. PCT Int. Appl. WO  2008115804 2008.

3. “Dithiocarbamates as IDO inhibitors and their preparation, pharmaceutical compositions and their use in the treatment of diseases” James B. Duhadaway, George C. Prendergast, William P. Malachowski, Alexander J. Muller. WO 2007050963 2007.

2. "Novel IDO (indoleamine 2,3-dioxygenase) inhibitors and methods of use" George C. Prendergast, Alexander J. Muller, James B. Duhadaway, and William P. Malachowski. WO 2004094409 2004.

1. "Novel methods for the treatment of cancer and viral infections" George C. Prendergast, Alexander J. Muller, James B. Duhadaway, and William P. Malachowski. WO 2004093871 2004.


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