Blanca Lopez
Dr. Peter Brodfuehrer

Biophysical Properties of AMPA Receptor on Xenopus oocytes

              The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and kainite receptors are non-NMDA receptors which mediate all known excitatory synaptic connections in the leech central pattern generator (CPG). There is not much information about non-NMDA receptors, but by introducing mRNA of AMPA receptors into Xenopus oocytes their properties can be analyzed through two-electrode voltage clamp experiments. Then the distribution and location of AMPA receptors would be determined by in situ hybridization.