Name: Jingyi (Alice) Tang
Advisor: William P. Malachowski
Department: Chemistry

IDO inhibitor

Inhibitors of indoleamine 2,3-dioxygenase (IDO) are designed to be potential drugs for the treatment of cancer. IDO is involved in controlling the host immune response to cancer. Cancer cells express IDO to limit the body’s immune response and thereby allow the cancer cells to grow. By creating inhibitors of IDO, we can limit the ability of cancer cells to evade detection.

Over the summer, I will be conducting synthetic organic chemistry to make newly designed inhibitors of IDO. These inhibitors are proposed to have a unique mechanism of inhibition: covalent or irreversible inhibition. That is, they are going to react with IDO and covalently link to the enzyme thereby killing it. My particular focus will be on irreversible inhibitors with a benzofuran core. The research activities in the lab on the IDO project include designing target compounds, ordering and gathering necessary chemicals and equipment to conduct the experiment, carrying out the experiment, monitoring the reaction, isolating target compounds using appropriate purification techniques, confirming purity and structure of the compound using NMR, GC/MS, LC/MS and IR techniques, and submitting the compounds to biological testing by the collaborator at Albert Einstein College of Medicine.