Naomi Chebet

Mentor: Jason Schmink

Chemistry department


Palladium-catalyzed cross-coupling of 2-aryl-1,3- dithianes and aryl iodonium salts


The focus of our research will be to develop new synthetic methods using transition metal catalysis. 2,2-diaryl-1,3-dithianes formed can be used as valuable intermediates in the synthesis of diaryl ketones, which have their applications in the drug industry. Palladium-catalyzed cross-coupling will be applied to synthesize 2,2-diaryl-1,3- dithianes. Initial work indicates that using a Pd(OAc)2/ NiXantphos catalyst system effects the desired transformation. Therefore, continued optimization will be undertaken to improve the reaction efficiency.

The previous research group reported the first palladium-catalyzed cross-coupling of 2,2-diaryl-1,3-dithianes with a range of aryl bromide derivatives. My goal this summer is to continue to use the same methodology to expand the scope of reaction by using alternative aryl electrophiles, including diaryl iodonium derivatives.