Renee Jingling Li
Mentor: Jia Tao
Medulloblastoma is the most common malignant pediatric brain tumor. However, previous researches indicate the current treatments of medulloblastoma are non-specific cytotoxic therapies, which will even cause significant secondary effects to the survivors’ developing brain. Previous studies have found subgroup enriched Somatic Copy Number Aberrations (SCNAs) 1, which suggests possibilities for future specific therapies while this research is attempt to identify targetable Single Nucleotide Polymorphisms (SNPs) 2 related to medulloblastoma. A SNP association detection tool, based on standard logistic regression and chi-square models, will be implemented and used to run on a dataset that includes the genome of 1087 medulloblastoma samples. A list of obtained SNPs will be studied through the results already found by other scientists to identify possible targetable SNPs. Then CMAP is utilized for searching possible anti-medulloblastoma drugs based on these SNPs.