Sarah Lew
Dr. Jason Schmink
Chemistry

Palladium-catalyzed cross-coupling of aryl bromides with 2,2-diphenyl-1,3-oxathiolane

The palladium-catalyzed cross-coupling of aryl bromides with 2,2-diphenyl-1,3-oxathiolane creates vinyl sulfides. Palladium acts as a shuttle of electrons that allows for bonds to form and makes it possible to create leaving groups for there to be an E2 reaction. The methodology found from this research will allow pharmaceutical companies who need vinyl sulfides to create them. Currently the research has focused on finding the best method for making the starting material, 2,2-diphenyl-1,3-oxathiolane, as it cannot be bought.