Synthesis of Molybdenum Pterin-dithioline Complexes
Enzymes containing Molybdenum are found in all forms of life on this planet, playing an important role in biology. The larger study at hand aims to use different molybdenum pterin-dithiolene complexes to learn about molybdenum containing enzymes and to model their natural appearance in a laboratory setting. A few different Molybdenum complexes are currently being studied, such as BMOPP, PEOPP, and BOPP. One Method used in this project is synthesizing the molecules needed in the study. This synthesis begins in two paths, the synthesis of the pterin group and the synthesis of the molybdenum centered portion. The different complexes being studied have slightly altered groups with the same general structure, and the behavior of each complex is therefore somewhat unique (see figure 1). The goal of my research for the summer is to learn both paths of synthesis for the molybdenum complexes being studied, to learn how to optimize these processes to get high yields and high quality products, and to learn how to analyze the results of these synthesis using techniques such as NMR, mass spectrometry, and other spectroscopic analysis.
Figure 1: A general model of Molybdenum pterin-dithioline complexes. Differences in the R groups make up the different complexes currently being studied. For example BMOPP has two methyl groups attached, and BOPP has one methyl group and one hydrogen molecule.