Palladium-catalyzed mono-γ-arylation of 7-methoxy-4-methylcoumarin
Authors: Mary E. Sexton, Ami Okazaki, Zhuowen Yu, Alexis van Venrooy, Jason R. Schmink, William P. Malachowski
Source: Tetrahedron Letters, DOI: 10.1016/j.tetlet.2019.151057
Publication Type: Article in a periodical
Abstract: Herein, we report the selective mono-γ-arylation of 7-methoxy-4-methylcoumarin under palladium-catalyzed conditions. The Buchwald G3 pre-catalyst in conjunction with either the Xantphos or N-Xantphos ligand proves to be highly reactive, engaging aryl iodides, bromides, chlorides, and triflates to effect the desired transformation. A wide range of functionality is tolerated, including the ability to activate heteroaryl halides in the transformation. The initial scope of aryl halides and limitations of this methodology are presented.